Dr. Andrew Huberman – Cannabis Health & Harms
Introduction
In this episode, Dr. Andrew Huberman dives into cannabis (marijuana), exploring the biological processes behind its effects on the mind and body. He covers its medical uses, as well as how it can influence libido, creativity, appetite, hormones, and more, while also addressing potential negative health impacts from both long-term and occasional use. Huberman highlights the factors that determine whether cannabis is beneficial or harmful, offering a balanced and scientific perspective.
He also explains how different strains—sativa, indica, and hybrid—can produce varying effects depending on THC-to-CBD ratio, dosage, and frequency of use. Huberman discusses why cannabis may alter speech patterns, contribute to anxiety or depression, and in some cases lead to paranoia. With cannabis laws rapidly changing, this episode provides valuable insights for users, medical professionals, educators, and anyone seeking to understand its effects on brain and body.
Dr. Andrew Huberman:
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Quotes
"Put simply, endogenous cannabinoids tend to decrease the probability that a neuron will release neurotransmitter. They're sort of a break on the system. They're a way of shutting down the communication between neurons, regulating it, not to make it completely quiet, but to adjust the levels with a lot of nuances."
"The endogenous cannabinoids are sometimes increasing neuronal communication. This can lead to increases in mood or increases in the likelihood that someone will talk a certain way or behave a certain way or feel a certain way. That can also lead to decreases in synaptic transmission, that is communication between neurons, in ways that will make somebody's mood lower, or will make them less hungry or more hungry."
"THC and CBD and other components of cannabis are highly what we call lipophilic. That is, they have an affinity toward, and they can actually pass through fatty tissues."
"In general, the prefrontal cortex is going to be activated by the sativa varieties, which is going to increase thinking and narrowly constrain focus to some activity … The indica varieties tend to lead to a suppression of activity in prefrontal cortex, believe it or not, and turn off thinking and planning. This is why indica varieties are often used for relaxation and for promoting sleep."
"Cannabis can increase dopamine transmission, that is dopamine levels, in certain brain areas, in particular brain areas involved in thinking and planning. So, cannabis increases dopamine in these areas. Elevated dopamine increases divergent thinking, and divergent thinking is associated with creativity, and there are studies that support the idea that cannabis can increase creativity."
"There's an entire literature on inspiratory, inhaling, versus expiratory laughs, and there's also a literature on cannabis altering the pattern of inspiratory and expiratory laughs. It almost sounds like a sarcastic laugh when, in fact, they may not be feeling sarcastic at all."
"Some people experience a lot of sexual arousal from cannabis and THC in particular, and some people do not, in fact, they experience suppression of sexual desire, and it's always been a little bit mysterious as to why that is."
"Whether or not you smoke or vape tobacco or cannabis, you are severely impairing the function of endothelial cells that make up the capillaries and blood vessels of your brain and body, and that is known to decrease cognitive capacity over time, increase probability of strokes, severely impact lung function, and also lead to things like peripheral neuropathies. It leads to sexual dysfunction, because of lack of blood flow to the genitals, can lead to other aspects of reproductive damage, including to the ovaries and testes."
"Endogenous cannabinoids are present in the adult brain and body and endogenous cannabinoids, it turns out, are also present in the developing fetus. In fact, endogenous cannabinoids are present at much greater levels in the developing fetus than they are after a child is born, and levels of endogenous cannabinoids actually go down across development."
"We now know, based on really solid epidemiological evidence, that depression is not a strong predictor of seeking out cannabis. It doesn't drive terribly many people to seek out cannabis use, but cannabis use, itself, makes people four times likelier to develop a chronic major depression. So, anxiety is increasing, depression is increasing, and this turns out to be especially relevant and important to young people."1
"If you look at individuals who start using cannabis, even younger, age 14, or even as young as 12, the probability of psychosis later in life, in particular schizophrenic or schizophrenic-like episodes more than doubles."2
1 A 2025 systematic review and meta-analysis of longitudinal studies found an association between cannabis use and a modestly increased risk of depression, with pooled results indicating approximately a 29% higher likelihood compared to non-users. The study highlights variability across populations and calls for further research into patterns of use and long-term mental health outcomes.
2 Cannabis use has been associated with an increased risk of psychosis in epidemiological research, particularly among those who begin use at a younger age or use it more frequently. Case-control studies of first-episode psychosis have also found higher odds of cannabis exposure patterns such as daily and long-term use among affected individuals compared with controls, supporting a relationship between cannabis use and psychosis-related outcomes.
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