As the unregulated drug supply becomes increasingly unpredictable, new combinations of synthetic substances are making overdoses more difficult to prevent and treat. This documentary investigates the emergence of "benzo dope" and "tranq"—street drugs containing fentanyl mixed with benzodiazepines or xylazine—and examines the devastating impact these combinations are having on people, families, healthcare providers, and frontline outreach workers. Through firsthand accounts and expert perspectives, this resource explores how a rapidly changing drug supply is reshaping the overdose crisis and reinforcing the importance of harm reduction, education, and timely access to care.